Poly(I:C)

Name: Poly(I:C)
Brand: Tocris Bioscience
SKU: 4287
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4287

(1)

Citations (90)

COA / SDS

TLR3 agonist

Key Product Details

Description:	TLR3 agonist
Chemical Name:	Polyinosinic-polycytidylic acid sodium salt

View Full Technical Details for Poly(I:C)

Technical Data
Citations / Reviews (1)

Biological Activity for Poly(I:C)

Poly(I:C) is a synthetic double-stranded RNA (dsRNA); endosomal Toll-like receptor 3 (TLR3) agonist. It also binds to the cytoplasmic receptors, retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA-5), elicits the secretion of type I interferon (IFN) and pro-inflammatory cytokines. Poly(I:C) is commonly used for immune system activation in vivo. Poly(I:C) also promotes maturation of hPSC-derived cardiomyocytes by modulating early Notch signaling and cardiomyogenic transcriptional programs. Poly(I:C) promotes generation of stable, mature dendritic cells in combination with TLR8 agonist CL 075 (Cat. No. 6142). Transfection into NIT-1 β cells induces β-cell apoptosis.

To prevent denaturation, this product should be reconstituted in solutions with physiological salt concentrations.

Technical Data for Poly(I:C)

Formula	(C₁₀H₁₃N₄O₈P)_x.(C₉H₁₄N₃O₈P)_x
Storage	Store at -20°C
CAS Number	42424-50-0
PubChem ID	32744
InChi Key	ACEVNMQDUCOKHT-ZLOOHWKQSA-N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Poly(I:C)

Solubility

Soluble to 3mg/ml in water

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References for Poly(I:C)

References are publications that support the biological activity of the product.

Waele A systematic review on poly(I:C) and poly-ICLC in glioblastoma: adjuvants coordinating the unlocking of immunotherapy. J.Exp.Clin.Cancer Res. 2021 PMID: 34172082
Biermann Epigenetic priming of human pluripotent stem cell-derived cardiac progenitor cells accelerates cardiomyocyte maturation. Stem Cells 2019 PMID: 31087611
Spranger Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J.Immunol. 2010 PMID: 20511554
West TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 2011 PMID: 21525932
Rouas Poly(I:C) used for human dendritic cell maturation preserves their ability to secondarily secrete bioactive IL-12. Int.Immunol. 2004 PMID: 15096480
Robbins Nuclear factor-κB translocation mediates double-stranded ribonucleic acid-induced NIT-1 beta-cell apoptosis and up-regulates caspase-12 and tumor necrosis factor-associated ligand (TRAIL). Endocrinology 2003 PMID: 12960048