Pomalidomide 4'-PEG2-amine

Name: Pomalidomide 4'-PEG2-amine
Brand: Tocris Bioscience
SKU: 6637
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6637

COA / SDS

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Key Product Details

Description:	Cereblon ligand with PEG linker and terminal amine for onward chemistry
Alternative Names:	Pomalidomide - linker 1
Chemical Name:	4-[[2-[2-(2-Aminoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
Purity:	≥95% (HPLC)
Molecular Weight:	440.88

View Full Technical Details for Pomalidomide 4'-PEG2-amine

Technical Data
Citations

Biological Activity for Pomalidomide 4'-PEG2-amine

Pomalidomide 4'-PEG2-amine is a functionalized cereblon ligand for PROTAC^® research and development; incorporates an E3 ligase ligand plus a PEG2 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

This product has been recently renamed. The previous name for this product was Pomalidomide - linker 1

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for Pomalidomide 4'-PEG2-amine

M. Wt	440.88
Formula	C₁₉H₂₄N₄O₆.HCl
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2245697-87-2
PubChem ID	134812848
InChi Key	BIBZEYIXXZHGNZ-UHFFFAOYSA-N
Smiles	NCCOCCOCCNC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Pomalidomide 4'-PEG2-amine

References are publications that support the biological activity of the product.

Remillard Degradation of the BAF complex factor BRD9 by heterobifunctional ligands. Angew.Chem.Int.Ed.Engl. 2017 PMID: 28418626