Pyridostatin pentahydrochloride

Name: Pyridostatin pentahydrochloride
Brand: Tocris Bioscience
SKU: 4763

Tocris Bioscience, part of Bio-Techne | Catalog # 4763

Citations (5)

COA / SDS

Stabilizes G-quadruplexes; induces DNA damage and cell cycle arrest

Key Product Details

Description:	Stabilizes G-quadruplexes; induces DNA damage and cell cycle arrest
Chemical Name:	4-(2-Aminoethoxy)N²,N⁶-bis[(4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinecarboxamide pentahydrochloride
Purity:	≥95% (HPLC)
Molecular Weight:	778.94

View Full Technical Details for Pyridostatin pentahydrochloride

Technical Data
Citations

Biological Activity for Pyridostatin pentahydrochloride

Binds and stabilizes G-quadruplexes, inducing DNA damage and cell cycle arrest (K_d = 490 nM); targets the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells. Also targets telomeric G-quadruplexes, inducing telomerase dysfunction. Activates the DNA-dependent protein kinase catalytic sunbunit (DNA-PKcs).

Technical Data for Pyridostatin pentahydrochloride

M. Wt	778.94
Formula	C₃₁H₃₂N₈O₅.5HCl
Storage	Desiccate at RT
Purity	≥95% (HPLC)
CAS Number	1781882-65-2
PubChem ID	78243739
InChi Key	SRIZPFGTXSQRFM-UHFFFAOYSA-N
Smiles	NCCOC1=CC(C(NC2=NC(C=CC=C3)=C3C(OCCN)=C2)=O)=NC(C(NC4=CC(OCCN)=C(C=CC=C5)C5=N4)=O)=C1.Cl.Cl.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pyridostatin pentahydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	15.58	20

Preparing Stock Solutions for Pyridostatin pentahydrochloride

The following data is based on the product molecular weight 778.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	6.42 mL	32.09 mL	64.19 mL
1 mM	1.28 mL	6.42 mL	12.84 mL
2 mM	0.64 mL	3.21 mL	6.42 mL
10 mM	0.13 mL	0.64 mL	1.28 mL

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References for Pyridostatin pentahydrochloride

References are publications that support the biological activity of the product.

Müller Small-molecule-mediated G-quadruplex isolation from human cells. Nat.Chem. 2010 PMID: 21107376
Koirala A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands. Nat.Chem. 2011 PMID: 21941250
Rodriguez Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat.Chem.Biol. 20112 PMID: 22306580