(R)-(-)-Phenylephrine hydrochloride

Name: ( R )-(-)-Phenylephrine hydrochloride
Brand: Tocris Bioscience
SKU: 2838

Tocris Bioscience, part of Bio-Techne | Catalog # 2838

(1)

Citations (24)

COA / SDS

α1 agonist

Key Product Details

Chemical Name:	(R)-(-)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride
Purity:	≥99%
Molecular Weight:	203.67 kDa

View Full Technical Details for (R)-(-)-Phenylephrine hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for (R)-(-)-Phenylephrine hydrochloride

(R)-(-)-Phenylephrine hydrochloride is a α₁-adrenoceptor agonist; pK_i values are 5.86, 4.87 and 4.70 for α_1D, α_1B and α_1A receptors respectively.

Scientific Data Examples for (R)-(-)-Phenylephrine hydrochloride

	Small molecules affect cardiomyocyte contraction rates. The effect of small molecules on cardiomyocyte contraction rate was assessed by monitoring intracellular calcium fluctuations, where an increase in calcium coincides with cardiomyocyte contraction. Cardiomyocytes were loaded with the fluorescent calcium indicator, Fluo-4, prior to small molecule treatment. Individual wells were first monitored for baseline rates of calcium fluctuation represented as beats per minute (bpm). Phenylephrine (3μM, Catalog # 2838), an alpha 1-adrenoceptor agonist, increased the calcium fluctuation rate of cardiomyocytes compared to untreated cells

Technical Data for (R)-(-)-Phenylephrine hydrochloride

M. Wt	203.67 kDa
Formula	C₉H₁₃NO₂.HCl
Storage	Desiccate at RT
Purity	≥99%
CAS Number	61-76-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (R)-(-)-Phenylephrine hydrochloride

Solubility

Soluble Soluble to 100 mM in water and to 100 mM in DMSO

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References for (R)-(-)-Phenylephrine hydrochloride

References are publications that support the biological activity of the product.

NZ Gungor, R Yamamoto, D Pare Glutamatergic and gabaergic ventral BNST neurons differ in their physiological properties and responsiveness to noradrenaline Neuropsychopharmacology, 2018;0(0):. 2018 PMID: 29704000
Minneman et al. Selectivity of agonists for cloned α₁-adrenergic receptor subtypes. Mol.Pharmacol., 1994;46:929 PMID: 7969082
Ford et al. Pharmacological pleiotropism of the human recombinant α_1A-adrenoceptor: implications for α₁-adrenoceptor classification. Br.J.Pharmacol., 1997;121:1127 PMID: 9249248
Morton et al. α_1A-adrenoceptors mediate contractions to phenylephrine in rabbit penile arteries. Br.J.Pharmacol., 2007;150:112 PMID: 17115072