(R)-(-)-Rolipram

Name: ( R )-(-)-Rolipram
Brand: Tocris Bioscience
SKU: 1349

Tocris Bioscience, part of Bio-Techne | Catalog # 1349

Citations (12)

COA / SDS

PDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905)

Key Product Details

Chemical Name:	(4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
Purity:	≥98%
Molecular Weight:	275.35 kDa

View Full Technical Details for (R)-(-)-Rolipram

Technical Data
Citations

Biological Activity for (R)-(-)-Rolipram

(R)-(-)-Rolipram is a more active enantiomer of the PDE4 inhibitor rolipram; 2-10-fold more potent than the S-(+) enantiomer.

Racemate and S-enantiomer also available.

Technical Data for (R)-(-)-Rolipram

M. Wt	275.35 kDa
Formula	C₁₆H₂₁NO₃
Storage	Store at RT
Purity	≥98%
CAS Number	85416-75-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (R)-(-)-Rolipram

Solubility

Soluble Soluble to 100 mM in ethanol and to 100 mM in DMSO

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References for (R)-(-)-Rolipram

References are publications that support the biological activity of the product.

Fox JT, Sakamuru S, Huang R High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. 2012 PMID: 22431602
Ohsawa et al. Inhibitory effects of rolipram on partially purified phosphodiesterase 4 from rat brains. Jpn.J.Pharmacol., 1998;77:147 PMID: 9681571
Owens et al. Human phosphodiesterase 4A: characterization of full-length and truncated enzymes expressed in COS cells. Biochem.J., 1997;326:53 PMID: 9337850
Schneider et al. Stereospecific binding of the antidepressant rolipram to brain protein structures. Eur.J.Pharmacol., 1986;127:105 PMID: 3019721