Rolipram

Name: Rolipram
Brand: Tocris Bioscience
SKU: 0905

Tocris Bioscience, part of Bio-Techne | Catalog # 0905

Citations (141)

COA / SDS

PDE4 inhibitor

Key Product Details

Description:	PDE4 inhibitor
Chemical Name:	4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
Purity:	≥98% (HPLC)
Molecular Weight:	275.35

View Full Technical Details for Rolipram

Technical Data
Citations

Biological Activity for Rolipram

Rolipram is a selective inhibitor of cAMP phosphodiesterase (PDE4) (IC₅₀ = 2.0 μM). Discriminates between two conformational states of PDE4 isoenzymes.

R-enantiomer also available.

Compound Libraries for Rolipram

Rolipram is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Rolipram

M. Wt	275.35
Formula	C₁₆H₂₁NO₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	61413-54-5
PubChem ID	5092
InChi Key	HJORMJIFDVBMOB-UHFFFAOYSA-N
Smiles	COC1=CC=C(C=C1OC1CCCC1)C1CNC(=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Rolipram

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	20.65	75
	ethanol	20.65	75

Preparing Stock Solutions for Rolipram

The following data is based on the product molecular weight 275.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	4.84 mL	24.21 mL	48.42 mL
3.75 mM	0.97 mL	4.84 mL	9.68 mL
7.5 mM	0.48 mL	2.42 mL	4.84 mL
37.5 mM	0.10 mL	0.48 mL	0.97 mL

Molarity Calculator

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Dilution Calculator

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Reconstitution Calculator

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References for Rolipram

References are publications that support the biological activity of the product.

O'Donnell Antidepressant-like effects of rolipram and other inhibitors of cyclic adenosine monophosphate phosphodiesterase on behaviour maintained by differential reinforcement of low response rate. J.Pharmacol.Exp.Ther. 1993 PMID: 8383740
Teixeira Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future? Trends Pharmacol.Sci. 1997 PMID: 9184477
Kato Rolipram, a cyclic AMP-selective phosphodiesterase inhibitor, reduces neuronal damage following cerebral ischemia in the gerbil. Eur.J.Pharmacol. 1995 PMID: 7713141