Rolipram

Name: Rolipram
Brand: Tocris Bioscience
SKU: 0905

Tocris Bioscience, part of Bio-Techne | Catalog # 0905

Citations (141)

COA / SDS

PDE4 inhibitor

Key Product Details

Chemical Name:	4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
Purity:	≥98%
Molecular Weight:	275.35 kDa

View Full Technical Details for Rolipram

Technical Data
Citations

Biological Activity for Rolipram

Rolipram is a selective inhibitor of cAMP phosphodiesterase (PDE4) (IC₅₀ = 2.0 μM). Discriminates between two conformational states of PDE4 isoenzymes.

R-enantiomer also available.

Technical Data for Rolipram

M. Wt	275.35 kDa
Formula	C₁₆H₂₁NO₃
Storage	Store at RT
Purity	≥98%
CAS Number	61413-54-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Rolipram

Solubility

Soluble Soluble to 75 mM in DMSO and to 75 mM in ethanol

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References for Rolipram

References are publications that support the biological activity of the product.

Fox JT, Sakamuru S, Huang R High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. 2012 PMID: 22431602
Kato et al. Rolipram, a cyclic AMP-selective phosphodiesterase inhibitor, reduces neuronal damage following cerebral ischemia in the gerbil. Eur.J.Pharmacol., 1995;272:107 PMID: 7713141
O'Donnell Antidepressant-like effects of rolipram and other inhibitors of cyclic adenosine monophosphate phosphodiesterase on behaviour maintained by differential reinforcement of low response rate. J.Pharmacol.Exp.Ther., 1993;264:1168 PMID: 8383740
Teixeira et al. Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future? Trends Pharmacol.Sci., 1997;18:164 PMID: 9184477