Rauwolscine hydrochloride

Name: Rauwolscine hydrochloride
Brand: Tocris Bioscience
SKU: 0891

Tocris Bioscience, part of Bio-Techne | Catalog # 0891

COA / SDS

α2 antagonist

Discontinued Product

0891 has been discontinued. View all Adrenergic alpha-2 Receptor Antagonists products.

Key Product Details

Description:	α₂ antagonist
Alternative Names:	α-Yohimbine hydrochloride,Corynanthidine
Chemical Name:	17α-Hydroxy-20α-yohimban-16β-carboxylic acid,methyl ester hydrochloride
Purity:	≥95% (HPLC)
Molecular Weight:	390.91

View Full Technical Details for Rauwolscine hydrochloride

Technical Data
Citations

Biological Activity for Rauwolscine hydrochloride

Rauwolscine hydrochloride is a standard α₂-adrenergic antagonist (K_i values are 3.5, 4.6, and 0.6 nM at cloned human α_2A, α_2B, and α_2C-adrenoceptors respectively). Partial agonist at 5-HT_1A receptors.

Diastereomer also avilable.

Technical Data for Rauwolscine hydrochloride

M. Wt	390.91
Formula	C₂₁H₂₆N₂O₃.HCl
Storage	Store at RT
Purity	≥95% (HPLC)
CAS Number	6211-32-1
PubChem ID	197067
InChi Key	PIPZGJSEDRMUAW-ZKKXXTDSSA-N
Smiles	[H][C@]12C4=C(C(C=CC=C5)=C5N4)CCN1C[C@]3([H])[C@]([C@H]([C@](OC)=O)[C@@H](O)CC3)([H])C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Rauwolscine hydrochloride

References are publications that support the biological activity of the product.

Hieble β- and γ-Adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J.Med.Chem. 1995 PMID: 7658428
Uhlen [3H]RS79948-197 binding to human, rat, guinea pig and pig α_2A-, α_2B-, and α_2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine. Eur.J.Pharmacol. 1998 PMID: 9551719
Arthur Partial agonist properties of rauwolscine and yohimbine for the inhibition of adenylyl cyclase by recombinant human 5-HT_1A receptors. Biochem.Pharmacol. 1993 PMID: 8517875

Rauwolscine hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 0891

Key Product Details

Biological Activity for Rauwolscine hydrochloride

Technical Data for Rauwolscine hydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Rauwolscine hydrochloride

Product Documents for Rauwolscine hydrochloride

COA

Certificate of Analysis

SDS

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