Yohimbine hydrochloride

Name: Yohimbine hydrochloride
Brand: Tocris Bioscience
SKU: 1127
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1127

(1)

Citations (45)

COA / SDS

Selective α2 antagonist

Key Product Details

Description:	Selective α₂ antagonist
Chemical Name:	17α-Hydroxyyohimban-16α-carboxylic acid methyl ester hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	390.91

View Full Technical Details for Yohimbine hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for Yohimbine hydrochloride

Yohimbine hydrochloride is a α₂-adrenoceptor antagonist (pK_i values are 8.52, 8.00 and 9.17 for human α_2A, α_2B and α_2C receptors respectively).

Diastereomer also available.

Technical Data for Yohimbine hydrochloride

M. Wt	390.91
Formula	C₂₁H₂₆N₂O₃.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	65-19-0
PubChem ID	6169
InChi Key	PIPZGJSEDRMUAW-VJDCAHTMSA-N
Smiles	[H][C@]12C4=C(C(C=CC=C5)=C5N4)CCN1C[C@@]3([H])[C@]([C@@H]([C@@](OC)=O)[C@@H](O)CC3)([H])C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Yohimbine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.82	20 with gentle warming

Preparing Stock Solutions for Yohimbine hydrochloride

The following data is based on the product molecular weight 390.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	12.79 mL	63.95 mL	127.91 mL
1 mM	2.56 mL	12.79 mL	25.58 mL
2 mM	1.28 mL	6.40 mL	12.79 mL
10 mM	0.26 mL	1.28 mL	2.56 mL

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Reconstitution Calculator

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References for Yohimbine hydrochloride

References are publications that support the biological activity of the product.

Goldberg and Robertson Yohimbine: a pharmacological probe for study of the &#945₂-adrenoceptor. Pharmacol.Rev.
Lalchandani Yohimbine dimers exhibiting selectivity for the human α_2c-adrenoceptor subtype. J.Pharmacol.Exp.Ther. 2002 PMID: 12438517
Redfern and Williams A re-evaluation of the role of α₂-adrenoceptors in the anxiogenic effects of yohimbine, using the selective antagonist delequamine in the rat. Br.J.Pharmacol. 1995 PMID: 8640349
Doxey Comparison of the α-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine. Naunyn Schmiedebergs Arch.Pharmacol. 1984 PMID: 6144048