Resiquimod

Name: Resiquimod
Brand: Tocris Bioscience
SKU: 4536

Tocris Bioscience, part of Bio-Techne | Catalog # 4536

(1)

Citations (13)

COA / SDS

Toll-like receptor 7 (TLR7) agonist

Key Product Details

Chemical Name:	1-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol
Purity:	≥98%

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Technical Data
Citations / Reviews (1)

Biological Activity for Resiquimod

Resiquimod is a toll-like receptor 7 (TLR7) agonist. Induces upregulation of IL-6, IL-12, IFN-γ and iNOS expression in mouse bone marrow-derived macrophages (BMMs). Inhibits RANKL-induced osteoclast differentiation in mouse BMMs and human peripheral blood monocytes. Also promotes the differentiation of MDSCs into macrophages and dendritic cells. Proinflammatory and antiviral.

Technical Data for Resiquimod

Formula	C₁₇H₂₂N₄O₂
Storage	Store at +4°C
Purity	≥98%
CAS Number	144875-48-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Resiquimod

Solubility

Soluble Soluble to 100 mM in DMSO and to 20 mM in ethanol

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References for Resiquimod

References are publications that support the biological activity of the product.

Derouazi M, Di Berardino-Besson W, Belnoue E, Hoepner S, Walther R, Benkhoucha M, Teta P, Dufour Y, Yacoub Maroun C, Salazar A, Martinvalet D, Dietrich P, Walker P Novel Cell-Penetrating Peptide-Based Vaccine Induces Robust CD4+ and CD8+ T Cell-Mediated Antitumor Immunity. Cancer Res, 2015;75(15):3020-31. 2015 PMID: 26116496
Martins K, Steffens J, van Tongeren S, Wells J, Bergeron A, Dickson S, Dye J, Salazar A, Bavari S Toll-like receptor agonist augments virus-like particle-mediated protection from Ebola virus with transient immune activation. PLoS ONE, 2014;9(2):e89735. 2014 PMID: 24586996
Lee et al. Resiquimod, a TLR7/8 agonist, promotes differentiation of myeloid-derived suppressor cells into macrophages and dendritic cells. Arch.Pharm.Res., 2014;37:1234 PMID: 24748512
Dockrell and Kinghorn Imiquimod and resiquimod as novel immunomodulators. J.Antimicrob.Chemother., 2001;48:751 PMID: 11733457
Miyamoto et al. R848, a toll-like receptor 7 agonist, inhibits osteoclast differentiation but not survival or bone-resorbing function of mature osteoclasts. Cytotechnology., 2012;64:331 PMID: 22358541
Wagner et al. Modulation of TH1 and Th2 cytokine production with the immune response modifiers, R-848 and imiq. Cell Immunol., 1999;191:10 PMID: 9918682

Resiquimod

Tocris Bioscience, part of Bio-Techne | Catalog # 4536

Key Product Details

Biological Activity for Resiquimod

Technical Data for Resiquimod

Solubility for Resiquimod

Dilution Calculator

Reconstitution Calculator

References for Resiquimod

Product Documents for Resiquimod

COA

Certificate of Analysis

SDS

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