Resiquimod

Name: Resiquimod
Brand: Tocris Bioscience
SKU: 4536
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4536

(1)

Citations (13)

COA / SDS

Toll-like receptor 7 (TLR7) agonist

Key Product Details

Description:	Toll-like receptor 7 (TLR7) agonist
Alternative Names:	R 848
Chemical Name:	1-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol
Purity:	≥98% (HPLC)
Molecular Weight:	314.38

View Full Technical Details for Resiquimod

Technical Data
Citations / Reviews (1)

Biological Activity for Resiquimod

Resiquimod is a toll-like receptor 7 (TLR7) agonist. Induces upregulation of IL-6, IL-12, IFN-γ and iNOS expression in mouse bone marrow-derived macrophages (BMMs). Inhibits RANKL-induced osteoclast differentiation in mouse BMMs and human peripheral blood monocytes. Also promotes the differentiation of MDSCs into macrophages and dendritic cells. Proinflammatory and antiviral.

Compound Libraries for Resiquimod

Resiquimod is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Resiquimod

M. Wt	314.38
Formula	C₁₇H₂₂N₄O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	144875-48-9
PubChem ID	159603
InChi Key	BXNMTOQRYBFHNZ-UHFFFAOYSA-N
Smiles	NC1=C3C(N(CC(C)(O)C)C(COCC)=N3)=C2C(C=CC=C2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Resiquimod

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	31.44	100
	ethanol	6.29	20

Preparing Stock Solutions for Resiquimod

The following data is based on the product molecular weight 314.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.18 mL	15.90 mL	31.81 mL
5 mM	0.64 mL	3.18 mL	6.36 mL
10 mM	0.32 mL	1.59 mL	3.18 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

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Reconstitution Calculator

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References for Resiquimod

References are publications that support the biological activity of the product.

Lee Resiquimod, a TLR7/8 agonist, promotes differentiation of myeloid-derived suppressor cells into macrophages and dendritic cells. Arch.Pharm.Res. 2014 PMID: 24748512
Miyamoto R848, a toll-like receptor 7 agonist, inhibits osteoclast differentiation but not survival or bone-resorbing function of mature osteoclasts. Cytotechnology. 2012 PMID: 22358541
Wagner Modulation of TH1 and Th2 cytokine production with the immune response modifiers, R-848 and imiq. Cell Immunol. 1999 PMID: 9918682
Dockrell and Kinghorn Imiquimod and resiquimod as novel immunomodulators. J.Antimicrob.Chemother. 2001 PMID: 11733457