Ro 25-6981 maleate

Name: Ro 25-6981 maleate
Brand: Tocris Bioscience
SKU: 1594
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1594

(1)

Citations (28)

COA / SDS

GluN2B-selective NMDA antagonist

Key Product Details

Description:	GluN2B-selective NMDA antagonist
Chemical Name:	(αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate
Purity:	≥98% (HPLC)
Molecular Weight:	455.55

View Full Technical Details for Ro 25-6981 maleate

Technical Data
Citations / Reviews (1)

Biological Activity for Ro 25-6981 maleate

Ro 25-6981 maleate is a potent and selective activity-dependent blocker of NMDA receptors containing the GluN2B (formally NR2B) subunit. IC₅₀values are 0.009 and 52 μM for cloned receptor subunit combinations GluN1C/GluN2B and GluN1C/GluN2A respectively. Displays neuroprotectant effects in vivo and in vitro.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Compound Libraries for Ro 25-6981 maleate

Ro 25-6981 maleate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Ro 25-6981 maleate

M. Wt	455.55
Formula	C₂₂H₂₉NO₂.C₄H₄O₄
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1312991-76-6
PubChem ID	53250677
InChi Key	FYJZEHCQSUBZDY-SEELMCCHSA-N
Smiles	OC(=O)\C=C/C(O)=O.C[C@@H](CN1CCC(CC2=CC=CC=C2)CC1)[C@@H](O)C1=CC=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ro 25-6981 maleate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	4.56	10 with gentle warming
	DMSO	45.55	100

Preparing Stock Solutions for Ro 25-6981 maleate

The following data is based on the product molecular weight 455.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.20 mL	10.98 mL	21.95 mL
5 mM	0.44 mL	2.20 mL	4.39 mL
10 mM	0.22 mL	1.10 mL	2.20 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Ro 25-6981 maleate

References are publications that support the biological activity of the product.

Kosowski and Liljequist The NR2B- selective N-MthD.-aspartate receptor antagonist Ro 25-6981 [(±)-(R*,S*)-α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidine propanol] potentiates the effect of nicotine on locomotor activity and DA release J.Pharmacol.Exp.Ther. 2004 PMID: 15256539
Lynch Pharmacological characterization of interactions of RO 25-6981 with the NR2B (ε2) subunit. Eur.J.Pharmacol. 2001 PMID: 11290368
Fischer Ro 25-6981, a highly potent and selective blocker of N-MthD.-aspartate receptors containing the NR2B subunit. Characterization in vitro. J.Pharmacol.Exp.Ther. 1997 PMID: 9400004