RS 127445 hydrochloride

Name: RS 127445 hydrochloride
Brand: Tocris Bioscience
SKU: 2993

Tocris Bioscience, part of Bio-Techne | Catalog # 2993

Citations (7)

COA / SDS

High affinity and selective 5-HT2B antagonist

Key Product Details

Description:	High affinity and selective 5-HT_2B antagonist
Alternative Names:	MT 500
Chemical Name:	4-(4-Fluoro-1-naphthalenyl)-6-(1-methylethyl)-2-pyrimidinamine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	317.79

View Full Technical Details for RS 127445 hydrochloride

Technical Data
Citations

Biological Activity for RS 127445 hydrochloride

RS 127445 hydrochloride is a high affinity 5-HT_2B receptor antagonist (pK_i = 9.5). Displays 1000-fold selectivity for 5-HT_2B with good bioavailability.

Compound Libraries for RS 127445 hydrochloride

RS 127445 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for RS 127445 hydrochloride

M. Wt	317.79
Formula	C₁₇H₁₆FN₃.HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	199864-86-3
PubChem ID	9905058
InChi Key	MKJPYBJBPRFMHL-UHFFFAOYSA-N
Smiles	FC1=C(C=CC=C2)C2=C(C3=CC(C(C)C)=NC(N)=N3)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RS 127445 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	31.78	100
	ethanol	31.78	100

Preparing Stock Solutions for RS 127445 hydrochloride

The following data is based on the product molecular weight 317.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.15 mL	15.73 mL	31.47 mL
5 mM	0.63 mL	3.15 mL	6.29 mL
10 mM	0.31 mL	1.57 mL	3.15 mL
50 mM	0.06 mL	0.31 mL	0.63 mL

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Reconstitution Calculator

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References for RS 127445 hydrochloride

References are publications that support the biological activity of the product.

Callebert Evidence for a control of plasma serotonin levels by 5-Hydroxytryptamine_2B receptors in mice. J.Pharmacol.Exp.Ther. 2006 PMID: 16461587
Bonhaus RS-127445: a selective, high affinity, orally bioavailable 5-HT_2B receptor antagonist. Br.J.Pharmacol. 1999 PMID: 10455251