5-HT2B Receptor Antagonists: Small Molecules and Peptides
5-HT2B is one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G protein-coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors, including 5-HT2B, mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele which blocks expression of 5-HTRB, and knockout studies in mice, suggest a role for 5-HT2B in impulsivity.
5 results for "5-HT2B Receptor Antagonists Small Molecules and Peptides" in Products
5 results for "5-HT2B Receptor Antagonists Small Molecules and Peptides" in Products
5-HT2B Receptor Antagonists: Small Molecules and Peptides
5-HT2B is one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G protein-coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors, including 5-HT2B, mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele which blocks expression of 5-HTRB, and knockout studies in mice, suggest a role for 5-HT2B in impulsivity.
Potent and selective 5-HT2B and 5-HT2C antagonist; orally active
| Chemical Name: | 3,5-Dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']dipyrrole-1(2H)-carboxamide hydrochloride |
| Purity: | ≥99% (HPLC) |
Selective 5-HT2B antagonist
| Chemical Name: | 1-[(2-Chloro-3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride |
| Purity: | ≥99% (HPLC) |
Potent, selective 5-HT2B antagonist
| Chemical Name: | N-(1-Methyl-1H-indolyl-5-yl)-N''-(3-methyl-5-isothiazolyl)urea |
| Purity: | ≥99% (HPLC) |
High affinity and selective 5-HT2B antagonist
| Alternate Names: | MT 500 |
| Chemical Name: | 4-(4-Fluoro-1-naphthalenyl)-6-(1-methylethyl)-2-pyrimidinamine hydrochloride |
| Purity: | ≥98% (HPLC) |
High affinity 5-HT2B antagonist; orally active
| Chemical Name: | 1-[(3,4-Dimethoxyphenyl)methy]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride |
| Purity: | ≥99% (HPLC) |
