S 25585

Name: S 25585
Brand: Tocris Bioscience
SKU: 3432

Tocris Bioscience, part of Bio-Techne | Catalog # 3432

COA / SDS

Potent and selective NPY Y5 receptor antagonist

Discontinued Product

3432 has been discontinued. View all NPY Receptor Antagonists products.

Key Product Details

Description:	Potent and selective NPY Y₅ receptor antagonist
Chemical Name:	1-Benzoyl-2-[[trans-4-[[[[2-nitro-4-(trifluoromethyl)phenyl]sulfonyl]amino]methyl]cyclohexyl]carbonyl]hydrazine
Purity:	≥98% (HPLC)
Molecular Weight:	528.5

View Full Technical Details for S 25585

Technical Data
Citations

Biological Activity for S 25585

Potent neuropeptide Y (NPY) Y₅ receptor antagonist (IC₅₀ values are 5.4, > 1000, > 10 000 and > 10 000 nM at Y₅, Y₁, Y₂ and Y₄ receptors respectively) that displays no affinity for a wide range of other receptors. Does not produce a conditioned taste aversion, suppress sodium appetite or cause pica in rats. Significantly inhibits NPY-induced feeding but not through blockade of Y₅ receptors.

Technical Data for S 25585

M. Wt	528.5
Formula	C₂₂H₂₃F₃N₄O₆S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	263849-50-9
PubChem ID	10029880
InChi Key	BRMJFKLHWFZWOQ-KOMQPUFPSA-N
Smiles	O=S(NC[C@H]1CC[C@H]([C@@](NNC(C3=CC=CC=C3)=O)=O)CC1)(C2=CC=C(C(F)(F)F)C=C2[N+]([O-])=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for S 25585

References are publications that support the biological activity of the product.

Della-Zuana A potent and selective NPY Y₅ antagonist reduces food intake but not through blockade of the NPY Y₅ receptor. Int.J.Obes.
Beauverger Functional characterization of human neuropeptide Y receptor subtype 5 specific antagonists using a luciferase reporter gene assay. Cell.Signal. 2005 PMID: 15601626

S 25585

Tocris Bioscience, part of Bio-Techne | Catalog # 3432

Key Product Details

Biological Activity for S 25585

Technical Data for S 25585

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for S 25585

Product Documents for S 25585

COA

Certificate of Analysis

SDS

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