SB 747651A dihydrochloride

Name: SB 747651A dihydrochloride
Brand: Tocris Bioscience
SKU: 4630
Rating: 4 (3 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4630

Citations (17)

COA / SDS

Potent MSK1 inhibitor; also inhibits other AGC group kinases

Key Product Details

Description:	Potent MSK1 inhibitor; also inhibits other AGC group kinases
Chemical Name:	2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-4-piperidinyl-1H-imidazo[4,5-c]pyridine-7-methanamine dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	415.32

View Full Technical Details for SB 747651A dihydrochloride

Technical Data
Citations

Biological Activity for SB 747651A dihydrochloride

SB 747651A dihydrochloride is a potent, ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor (IC₅₀ = 11 nM in an in vitro kinase assay); targets the N-terminal kinase domain. Inhibits MSK1, MSK2, PKA, PKB, RSK and p70^S6K activity in cells. Blocks IL-10 production in macrophages.

Licensing Information

Sold with the permission of GlaxoSmithKline.

Compound Libraries for SB 747651A dihydrochloride

SB 747651A dihydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for SB 747651A dihydrochloride

M. Wt	415.32
Formula	C₁₆H₂₂N₈O.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1781882-72-1
PubChem ID	90488958
InChi Key	NRRCQHARLPNLHJ-UHFFFAOYSA-N
Smiles	NC1=NON=C1C3=NC2=CN=CC(CNC4CCNCC4)=C2N3CC.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 747651A dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	20.77	50
	DMSO	20.77	50

Preparing Stock Solutions for SB 747651A dihydrochloride

The following data is based on the product molecular weight 415.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.82 mL	24.08 mL	48.16 mL
2.5 mM	0.96 mL	4.82 mL	9.63 mL
5 mM	0.48 mL	2.41 mL	4.82 mL
25 mM	0.10 mL	0.48 mL	0.96 mL

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References for SB 747651A dihydrochloride

References are publications that support the biological activity of the product.

Bamford (1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: further optimisation as highly potent and selective MSK-1-inhibitors. Bioorg.Med.Chem.Lett. 2005 PMID: 15955699
Naqvi Characterization of the cellular action of the MSK inhibitor SB-747651A. Biochem.J. 2012 PMID: 21970321
Bamford (1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: a novel class of potent MSK-1-inhibitors. Bioorg.Med.Chem.Lett. 2005 PMID: 15950465