SJ 1008066

Name: SJ 1008066
Brand: Tocris Bioscience
SKU: 7542

Tocris Bioscience, part of Bio-Techne | Catalog # 7542

COA / SDS

MAGE-A11 inhibitor; disrupts MAGE-A11:PCF11 interaction

Key Product Details

Description:	MAGE-A11 inhibitor; disrupts MAGE-A11:PCF11 interaction
Chemical Name:	N¹-((1H-Indol-5-yl)methyl)-N³-(quinolin-4-yl)propane-1,3-diamine
Purity:	≥98% (HPLC)
Molecular Weight:	330.44

View Full Technical Details for SJ 1008066

Technical Data
Citations

Biological Activity for SJ 1008066

SJ 1008066 is a cell permeable inhibitor of testis-restricted melanoma antigen protein MAGE-A11 (IC₅₀ = 0.13 μM). SJ 1008066 binds to the MAGE homology domain (MHD) and disrupts MAGE-A11:PCF11 interaction. SJ1008066 exhibits no effect on MAGE-A3:AMPKα1 or MAGE-F1:MMS19 interactions in TR-FRET and cell lysate pulldown assays.

Licensing Information

Sold under license from St. Jude Children's Research Hospital.

Compound Libraries for SJ 1008066

SJ 1008066 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SJ 1008066

M. Wt	330.44
Formula	C₂₁H₂₂N₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2758867-71-7
PubChem ID	162444676
InChi Key	UMJWTJVGTTUEQK-UHFFFAOYSA-N
Smiles	C12=C(C=CC=C2)C(NCCCNCC3=CC4=C(C=C3)NC=C4)=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SJ 1008066

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	33.04	100

Preparing Stock Solutions for SJ 1008066

The following data is based on the product molecular weight 330.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.03 mL	15.13 mL	30.26 mL
5 mM	0.61 mL	3.03 mL	6.05 mL
10 mM	0.30 mL	1.51 mL	3.03 mL
50 mM	0.06 mL	0.30 mL	0.61 mL

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References for SJ 1008066

References are publications that support the biological activity of the product.

Yang Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases. Nat.Commun. 2020 PMID: 33004795