SR 10067

Name: SR 10067
Brand: Tocris Bioscience
SKU: 6038

Tocris Bioscience, part of Bio-Techne | Catalog # 6038

Citations (2)

COA / SDS

Selective Rev-Erbα/β agonist; anxiolytic

Key Product Details

Description:	Selective Rev-Erbα/β agonist; anxiolytic
Chemical Name:	[3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone
Purity:	≥98% (HPLC)
Molecular Weight:	465.58

View Full Technical Details for SR 10067

Technical Data
Citations

Biological Activity for SR 10067

SR 10067 is a selective Rev-Erbα/β agonist (IC₅₀ values are 160 and 170 nM for Rev-Erbβ and Rev-Erbα respectively). Exhibits no significant activity against a wide range of nuclear receptors, other receptors, ion channels and transporters at 20 μM. Increases wakefulness, reduces REM and slow wave sleep in vivo. Also reduces anxiety-like behavior in marble-burying assay. Cell permeable and brain penetrant.

Technical Data for SR 10067

M. Wt	465.58
Formula	C₃₁H₃₁NO₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1380548-02-6
PubChem ID	60168097
InChi Key	MOPAGKWBFUICQT-UHFFFAOYSA-N
Smiles	CC(C)(OC1=CC=C(C=C1)OCC2CC3=CC=CC=C3CN2C(C4=CC=CC5=C4C=CC=C5)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SR 10067

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	2.33	5 with gentle warming

Preparing Stock Solutions for SR 10067

The following data is based on the product molecular weight 465.58.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	42.96 mL	214.79 mL	429.57 mL
0.25 mM	8.59 mL	42.96 mL	85.91 mL
0.5 mM	4.30 mL	21.48 mL	42.96 mL
2.5 mM	0.86 mL	4.30 mL	8.59 mL

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References for SR 10067

References are publications that support the biological activity of the product.

Thevis Emerging drugs affecting skeletal muscle function and mitochondrial biogenesis - Potential implications for sports drug testing programs. Rapid Commun. Mass Spectrom 2016 PMID: 26842585
Banerjee Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour. Nat.Commun. 2014 PMID: 25536025