SRT 1720

Name: SRT 1720
Brand: Tocris Bioscience
SKU: 7558

Tocris Bioscience, part of Bio-Techne | Catalog # 7558

Citations (5)

COA / SDS

Selective SIRT1 activator; induces autophagy and mitochondrial biogenesis

Key Product Details

Description:	Selective SIRT1 activator; induces autophagy and mitochondrial biogenesis
Chemical Name:	N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	469.56

View Full Technical Details for SRT 1720

Technical Data
Citations

Biological Activity for SRT 1720

SRT 1720 is selective SIRT 1 activator (EC₅₀ = 0.16 μM). SRT 1720 inhibits growth of bladder cancer organoids and xenografts (IC₅₀ = 0.35 μM) and induces autophagy. In vitro, SRT 1720 increases mitochondrial biogenesis and recovery after oxidation injury and reduces palmitate-induced insulin resistance. Also improves survival and healthspan of obese mice.

Technical Data for SRT 1720

M. Wt	469.56
Formula	C₂₅H₂₃N₇OS
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	925434-55-5
PubChem ID	24180125
InChi Key	IASPBORHOMBZMY-UHFFFAOYSA-N
Smiles	O=C(NC=1C=CC=CC1C=2N=C3SC=C(N3C2)CN4CCNCC4)C5=NC6=CC=CC=C6N=C5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SRT 1720

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	2.35	5

Preparing Stock Solutions for SRT 1720

The following data is based on the product molecular weight 469.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	42.59 mL	212.97 mL	425.93 mL
0.25 mM	8.52 mL	42.59 mL	85.19 mL
0.5 mM	4.26 mL	21.30 mL	42.59 mL
2.5 mM	0.85 mL	4.26 mL	8.52 mL

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References for SRT 1720

References are publications that support the biological activity of the product.

Funk SRT1720 induces mitochondrial biogenesis and rescues mitochondrial function after oxidant injury in renal proximal tubule cells. J.Pharmacol.Exp.Ther. 2010 PMID: 20103585
Luo Sirt1 promotes autophagy and inhibits apoptosis to protect cardiomyocytes from hypoxic stress. Int.J.Mol.Med. 2019 PMID: 30864731
Paramesha Sirt1 and Sirt3 activation improved cardiac function of diabetic rats via modulation of mitochondrial function. Antioxidants (Basel) 2021 PMID: 33668369
Tan SRT1720 inhibits the growth of bladder cancer in organoids and murine models through the SIRT1-HIF axis. Oncogene 2021 PMID: 34471236