STOCK2S 26016

Name: STOCK2S 26016
Brand: Tocris Bioscience
SKU: 5570

Tocris Bioscience, part of Bio-Techne | Catalog # 5570

Citations (2)

COA / SDS

Lysine deficient protein kinase (WNK) signaling inhibitor

Key Product Details

Description:	Lysine deficient protein kinase (WNK) signaling inhibitor
Chemical Name:	7-Ethoxy-N³-(2-furanylmethyl)-3,9-acridinediamine
Purity:	≥98% (HPLC)
Molecular Weight:	333.38

View Full Technical Details for STOCK2S 26016

Technical Data
Citations

Biological Activity for STOCK2S 26016

STOCK2S 26016 is a lysine deficient protein kinase (WNK) signaling inhibitor (IC₅₀ = 16 μM). Inhibits binding of WNK1 and WNK4 to SPAK and phosphorylation of downstream transporters, NKCC1 and NCC, in mouse vascular smooth muscle and distal convoluted tubule cell cultures exposed to hypotonic shock, respectively. Inhibits STK39 activation; inhibits migration and invasion of cancer cells in vitro.

Technical Data for STOCK2S 26016

M. Wt	333.38
Formula	C₂₀H₁₉N₃O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	332922-63-1
PubChem ID	3135086
InChi Key	PGNWQNJXXLPZEL-UHFFFAOYSA-N
Smiles	NC1=C2C(C=CC(OCC)=C2)=NC3=C1C=CC(NCC4=CC=CO4)=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for STOCK2S 26016

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.34	100
	ethanol	16.67	50

Preparing Stock Solutions for STOCK2S 26016

The following data is based on the product molecular weight 333.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.00 mL	15.00 mL	30.00 mL
5 mM	0.60 mL	3.00 mL	6.00 mL
10 mM	0.30 mL	1.50 mL	3.00 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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References for STOCK2S 26016

References are publications that support the biological activity of the product.

Qiu STK39 promotes breast cancer invasion and metastasis by increasing SNAI1 activity upon phosphorylation. Theranostics 2021 PMID: 34335956
Mori Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy. Biochem.J. 2013 PMID: 23981180