SU 6656

Name: SU 6656
Brand: Tocris Bioscience
SKU: 6475

Tocris Bioscience, part of Bio-Techne | Catalog # 6475

Citations (27)

COA / SDS

Potent ATP-competitive Src family kinase inhibitor; also AMPK inhibitor; cell permeable

Key Product Details

Description:	Potent ATP-competitive Src family kinase inhibitor; also AMPK inhibitor; cell permeable
Chemical Name:	2,3-Dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-1H-indole-5-sulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	371.45

View Full Technical Details for SU 6656

Technical Data
Citations

Biological Activity for SU 6656

SU 6656 is a potent ATP-competitive Src family kinase inhibitor (IC₅₀ values are 0.02, 0.13, 0.17, 0.28 and 6.88 nM for Yes, Lyn, Fyn, Src and Lck, respectively). Exhibits > 6.5 fold selectivity for Src family over other kinases. Also AMPK inhibitor (IC₅₀ = 0.22 μM for the α2 kinase domain). Cell permeable.

Technical Data for SU 6656

M. Wt	371.45
Formula	C₁₉H₂₁N₃O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	330161-87-0
PubChem ID	5312137
InChi Key	LOGJQOUIVKBFGH-YBEGLDIGSA-N
Smiles	CN(S(=O)(C1=CC=C2NC(/C(C2=C1)=C\C3=CC4=C(N3)CCCC4)=O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SU 6656

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	37.15	100

Preparing Stock Solutions for SU 6656

The following data is based on the product molecular weight 371.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.69 mL	13.46 mL	26.92 mL
5 mM	0.54 mL	2.69 mL	5.38 mL
10 mM	0.27 mL	1.35 mL	2.69 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References for SU 6656

References are publications that support the biological activity of the product.

Blake SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Mol.Cell Biol. 2000 PMID: 11074000
Ross Mechanisms of paradoxical activation of AMPK by the kinase inhibitors SU6656 and sora. Cell.Chem.Biol. 2017 PMID: 28625738