T 0070907

Name: T 0070907
Brand: Tocris Bioscience
SKU: 2301
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2301

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Citations (52)

COA / SDS

Highly potent and selective covalent PPARγ antagonist

Key Product Details

Description:	Highly potent and selective covalent PPARγ antagonist
Chemical Name:	2-Chloro-5-nitro-N-4-pyridinylbenzamide
Purity:	≥99% (HPLC)
Molecular Weight:	277.67

View Full Technical Details for T 0070907

Technical Data
Citations / Reviews (1)

Biological Activity for T 0070907

T 0070907 is a potent and selective irreversible PPARγ antagonist (IC₅₀ = 1 nM). Displays > 800-fold selectivity for PPARγ over PPARα and PPARδ. Blocks transcriptional activity of PPARγ in vitro and inhibits Rosiglitazone-induced adipogenesis.

Compound Libraries for T 0070907

T 0070907 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for T 0070907

M. Wt	277.67
Formula	C₁₂H₈N₃O₃Cl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	313516-66-4
PubChem ID	2777391
InChi Key	FRPJSHKMZHWJBE-UHFFFAOYSA-N
Smiles	[O-][N+](=O)C1=CC=C(Cl)C(=C1)C(=O)NC1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for T 0070907

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	27.8	100
	1eq. HCl	27.77	100

Preparing Stock Solutions for T 0070907

The following data is based on the product molecular weight 277.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.60 mL	18.01 mL	36.01 mL
5 mM	0.72 mL	3.60 mL	7.20 mL
10 mM	0.36 mL	1.80 mL	3.60 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

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References for T 0070907

References are publications that support the biological activity of the product.

Rockwell and Kaminski A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes. J.Pharmacol.Exp.Ther. 2004 PMID: 15284281
Schaefer Peroxisome proliferator-activated receptor γ inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cells. Cancer Res. 2005 PMID: 15781638
Lee T0070907, a selective ligand for peroxisome proliferator-activated receptor γ, functions as an antagonist of biochemical and cellular activities. J.Biol.Chem. 2002 PMID: 11877444