TAME hydrochloride

Name: TAME hydrochloride
Brand: Tocris Bioscience
SKU: 4506

Tocris Bioscience, part of Bio-Techne | Catalog # 4506

Citations (1)

COA / SDS

Ubiquitin ligase APC/C inhibitor; promotes Cdc20 autoubiquitination

Discontinued Product

4506 has been discontinued. View all Ubiquitin Ligase (E3) Inhibitors products.

Key Product Details

Description:	Ubiquitin ligase APC/C inhibitor; promotes Cdc20 autoubiquitination
Chemical Name:	N²-[(4-Methylphenyl)sulfonyl]-L-arginine methyl ester hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	378.87

View Full Technical Details for TAME hydrochloride

Technical Data
Citations

Biological Activity for TAME hydrochloride

TAME hydrochloride is a competitive inhibitor of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C); promotes Cdc20 autoubiquitination. Inhibits cyclin proteolysis in mitotic Xenopus oocyte extracts (IC₅₀ = 12 μM) and blocks cyclin degradation in interphase extract.

Technical Data for TAME hydrochloride

M. Wt	378.87
Formula	C₁₄H₂₂N₄O₄S.HCl
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	1784-03-8
PubChem ID	2723792
InChi Key	JIQFFACVQXXHMY-YDALLXLXSA-N
Smiles	NC(NCCC[C@H](NS(C1=CC=C(C)C=C1)(=O)=O)C(OC)=O)=N.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for TAME hydrochloride

References are publications that support the biological activity of the product.

Zeng & King An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nat.Chem.Biol. 2012 PMID: 22366722
Zeng Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell. 2010 PMID: 20951947

TAME hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4506

Key Product Details

Biological Activity for TAME hydrochloride

Technical Data for TAME hydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for TAME hydrochloride

Product Documents for TAME hydrochloride

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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