TGX 221

Name: TGX 221
Brand: Tocris Bioscience
SKU: 5832

Tocris Bioscience, part of Bio-Techne | Catalog # 5832

Citations (6)

COA / SDS

Potent and selective PI 3-kinase β inhibitor

Key Product Details

Description:	Potent and selective PI 3-kinase β inhibitor
Chemical Name:	7-Methyl-2-(4-morpholinyl)-9-[1-(phenylamino)ethyl]-4H-pyrido[1,2-a]pyrimidin-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	364.44

View Full Technical Details for TGX 221

Technical Data
Citations

Biological Activity for TGX 221

TGX 221 is a potent and selective PI 3-kinase β inhibitor (IC₅₀ values are 0.007, 0.1, 3.5 and 5 μM for the β, δ, γ and α isoforms, respectively). Shows >1,000-fold selectively for PI 3-kinase β over a range of other kinases. Inhibits thrombus formation in animal models.

Compound Libraries for TGX 221

TGX 221 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for TGX 221

M. Wt	364.44
Formula	C₂₁H₂₄N₄O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	663619-89-4
PubChem ID	9907093
InChi Key	CPRAGQJXBLMUEL-UHFFFAOYSA-N
Smiles	CC(C1=CC(C)=CN2C(C=C(N3CCOCC3)N=C12)=O)NC4=CC=CC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TGX 221

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	18.22	50

Preparing Stock Solutions for TGX 221

The following data is based on the product molecular weight 364.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.49 mL	27.44 mL	54.88 mL
2.5 mM	1.10 mL	5.49 mL	10.98 mL
5 mM	0.55 mL	2.74 mL	5.49 mL
25 mM	0.11 mL	0.55 mL	1.10 mL

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References for TGX 221

References are publications that support the biological activity of the product.

Jackson PI 3-kinase p110β: a new target for antithrombotic therapy. Nat.Med. 2005 PMID: 15834429
Condliffe Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood 2005 PMID: 15878979