Thalidomide 4'-ether-PEG2-alkyne

Name: Thalidomide 4'-ether-PEG2-alkyne
Brand: Tocris Bioscience
SKU: 6686

Tocris Bioscience, part of Bio-Techne | Catalog # 6686

COA / SDS

Cereblon ligand with PEG linker and terminal alkyne for onward chemistry

Key Product Details

Description:	Cereblon ligand with PEG linker and terminal alkyne for onward chemistry
Alternative Names:	Thalidomide - linker 5
Chemical Name:	2-(2,6-Dioxo-3-piperidinyl)-4-[2-[2-(2-propyn-1-yloxy)oxy]ethoxy]-1H-isoindole-1,3(2H)dione
Purity:	≥95% (HPLC)
Molecular Weight:	400.38

View Full Technical Details for Thalidomide 4'-ether-PEG2-alkyne

Technical Data
Citations

Biological Activity for Thalidomide 4'-ether-PEG2-alkyne

Thalidomide 4'-ether-PEG2-alkyne is a functionalized cereblon ligand for PROTAC^® research and development; incorporates an E3 ligase ligand plus a PEG2 linker with alkyne terminal ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTACs R&D.

This product has been recently renamed. The previous name for this product was Thalidomide - linker 5

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for Thalidomide 4'-ether-PEG2-alkyne

M. Wt	400.38
Formula	C₂₀H₂₀N₂O₇
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2098487-52-4
PubChem ID	131988624
InChi Key	XJWGDRINRIEEJD-UHFFFAOYSA-N
Smiles	O=C1N(C(C2=C(C=CC=C12)OCCOCCOCC#C)=O)C3CCC(NC3=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Thalidomide 4'-ether-PEG2-alkyne

References are publications that support the biological activity of the product.

Remillard Degradation of the BAF complex factor BRD9 by heterobifunctional ligands. Angew.Chem.Int.Ed.Engl. 2017 PMID: 28418626