TNP

Name: TNP
Brand: Tocris Bioscience
SKU: 3946

Tocris Bioscience, part of Bio-Techne | Catalog # 3946

Citations (2)

COA / SDS

Inhibitor of IP6K; also inhibits IP3K

Key Product Details

Description:	Inhibitor of IP6K; also inhibits IP3K
Chemical Name:	N⁶-[(4-nitrophenyl)methyl]-N²-[[3-(trifluoromethyl)phenyl]methyl]-9H-Purine-2,6-diamine
Purity:	≥97% (HPLC)
Molecular Weight:	443.38

View Full Technical Details for TNP

Technical Data
Citations

Biological Activity for TNP

TNP is a reversible inositol hexakisphosphate kinase (IP6K) inhibitor (IC₅₀ = 0.47 μM for inhibition of InsP₇ formation). Also inhibits inositol 1,4,5-trisphosphate 3-kinase (IP3K) (IC₅₀ = 10.2 μM). Binds to the ATP binding site of IP3K (K_i = 4.3 μM).

Technical Data for TNP

M. Wt	443.38
Formula	C₂₀H₁₆F₃N₇O₂
Storage	Store at +4°C
Purity	≥97% (HPLC)
CAS Number	519178-28-0
PubChem ID	16760513
InChi Key	DDSBPUYZPWNNGH-UHFFFAOYSA-N
Smiles	O=[N+](C(C=C4)=CC=C4CNC1=C2C(NC=N2)=NC(NCC3=CC=CC(C(F)(F)F)=C3)=N1)[O-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TNP

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	44.34	100
	ethanol	11.08	25

Preparing Stock Solutions for TNP

The following data is based on the product molecular weight 443.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.26 mL	11.28 mL	22.55 mL
5 mM	0.45 mL	2.26 mL	4.51 mL
10 mM	0.23 mL	1.13 mL	2.26 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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References for TNP

References are publications that support the biological activity of the product.

Chang Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase. Chembiochem 2002 PMID: 12210991
Padmanabhan Characterization of a selective inhibitor of inositol hexakisphosphate kinases. Use in defining biological roles and metabolic relationships of inositol pyrophosphates. J.Biol.Chem. 2009 PMID: 19208622

TNP