trans-ISRIB

Name: trans-ISRIB
Brand: Tocris Bioscience
SKU: 5284
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5284

(3)

Citations (49)

COA / SDS

Integrated stress response (ISR) inhibitor

Key Product Details

Chemical Name:	N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)acetamide]
Purity:	≥99%

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Technical Data
Citations / Reviews (3)

Biological Activity for trans-ISRIB

trans-ISRIB is a potent integrated stress response (ISR) inhibitor; reverses the effects of eIF2α phosphorylation (IC₅₀ = 5 nM) and restores cell translation capacity. Acts downstream of PERK, targeting interactions between eIF2α kinases and elF2B. Blocks ATF4 production without altering the IRE1 or ATF6 responses in vitro. Displays memory enhancement in hippocampus-dependent spatial and fear-associated learning in rodents. trans-ISRIB promotes survival of pluripotent stem cells in culture when used in combination with Chroman 1 (Cat. No. 7163), Emricasan (Cat. No. 7310), and Polyamine Supplement x1000 (lyophilized) (Cat. No. 7739), a combination known as CEPT. When used as part of the CEPT cocktail, trans-ISRIB improves survival of differentiated cells following cryopreservation. Brain penetrant.

Technical Data for trans-ISRIB

Formula	C₂₂H₂₄Cl₂N₂O₄
Storage	Store at +4°C
Purity	≥99%
CAS Number	1597403-47-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for trans-ISRIB

Solubility

Soluble Soluble to 10 mM in DMSO with gentle warming

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References for trans-ISRIB

References are publications that support the biological activity of the product.

S Liu, Y Liu, K Minami, A Chen, Q Wan, Y Yin, L Gan, A Xu, N Matsuura, M Koizumi, Y Liu, S Na, J Li, H Nakshatri, BY Li, H Yokota Inhibiting checkpoint kinase 1 protects bone from bone resorption by mammary tumor in a mouse model Oncotarget, 2018;9(10):9364-9378. 2018 PMID: 29507695
Sidrauski et al. Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife, 2013;2:e00498 PMID: 23741617
Sekine et al. Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound. Science, 2015;348:1027 PMID: 25858979
Hinnebusch Cell biology. Blocking stress response for better memory? Science, 2015;348:967 PMID: 26023119

trans-ISRIB

Tocris Bioscience, part of Bio-Techne | Catalog # 5284

Key Product Details

Biological Activity for trans-ISRIB

Technical Data for trans-ISRIB

Solubility for trans-ISRIB

Dilution Calculator

Reconstitution Calculator

References for trans-ISRIB

Product Documents for trans-ISRIB

COA

Certificate of Analysis

SDS

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