VH 032 amide-PEG3-BCN

Name: VH 032 amide-PEG3-BCN
Brand: Tocris Bioscience
SKU: 8123

Tocris Bioscience, part of Bio-Techne | Catalog # 8123

COA / SDS

Functionalized VHL building block for copper-free click chemistry

Key Product Details

Description:	Functionalized VHL building block for copper-free click chemistry
Chemical Name:	((1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl ((S)-14-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-15,15-dimethyl-12-oxo-3,6,9-trioxa-13-azahexadecyl)carbamate
Purity:	≥90% (HPLC)
Molecular Weight:	810.02

View Full Technical Details for VH 032 amide-PEG3-BCN

Technical Data
Citations

Biological Activity for VH 032 amide-PEG3-BCN

VH 032 amide-PEG3-BCN is a functionalized von Hippel Lindau (VHL) protein ligand for PROTAC^® research and development. Incorporates an E3 ligase ligand plus a PEG3 linker with terminal bicyclooctyne (BCN). It can be used for copper-free strain-promoted azide-alkyne cycloaddition (SPAAC) reaction. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for VH 032 amide-PEG3-BCN

M. Wt	810.02
Formula	C₄₂H₅₉N₅O₉S
Storage	Store at -20°C
Purity	≥90% (HPLC)
CAS Number	2876198-36-4
PubChem ID	169450546
InChi Key	WLQVZOBNMRIBKF-LLQRHEORSA-N
Smiles	O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)[C@H](C(C)(C)C)NC(CCOCCOCCOCCNC(OC[C@H]4[C@]5([H])[C@@]4([H])CCC#CCC5)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for VH 032 amide-PEG3-BCN

References are publications that support the biological activity of the product.

Liu TF-PROTACs enable targeted degradation of transcription factors. J.Am.Chem.Soc. 2021 PMID: 34100597