Wortmannin

Name: Wortmannin
Brand: Tocris Bioscience
SKU: 1232
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1232

(2)

Citations (276)

COA / SDS

Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1

Key Product Details

Description:	Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1
Alternative Names:	SL-2052
Chemical Name:	(1S,6bR,9aS,11R,11bR) 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5,-h]-2-h]-2-benzopyran-3,6,9-trione
Purity:	≥98% (HPLC)
Molecular Weight:	428.44

View Full Technical Details for Wortmannin

Technical Data
Citations / Reviews (2)

Biological Activity for Wortmannin

Wortmannin is a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC₅₀ = 2 - 4 nM). Also potently inhibits polo-like kinase 1 (PLK1) (IC₅₀ = 5.8 nM).

Technical Data for Wortmannin

M. Wt	428.44
Formula	C₂₃H₂₄O₈
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	19545-26-7
PubChem ID	3003565
InChi Key	QDLHCMPXEPAAMD-ZGSWIPFCSA-N
Smiles	O=C(C4=CO5)O[C@H](COC)[C@@]1(C)C4=C5C(C2=C1[C@H](OC(C)=O)C[C@@]3(C)C2CCC3=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Wortmannin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	21.42	50

Preparing Stock Solutions for Wortmannin

The following data is based on the product molecular weight 428.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.67 mL	23.34 mL	46.68 mL
2.5 mM	0.93 mL	4.67 mL	9.34 mL
5 mM	0.47 mL	2.33 mL	4.67 mL
25 mM	0.09 mL	0.47 mL	0.93 mL

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Reconstitution Calculator

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References for Wortmannin

References are publications that support the biological activity of the product.

Schultz In vitro and in vivo antitumor activity of the phosphatidylinositol-3-kinase inhibitor wortmannin. Anticancer Res. 1995 PMID: 7653991
Liu Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase. Chem.Biol. 2005 PMID: 15664519
Powis Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase. Cancer Res. 1994 PMID: 8162590
Arcaro and Wymann Wortmannin is a potent phophatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem.J. 1993 PMID: 8257416