XAV 939

Name: XAV 939
Brand: Tocris Bioscience
SKU: 3748
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3748

(1)

Citations (268)

COA / SDS

Potent tankyrase inhibitor

Key Product Details

Description:	Potent tankyrase inhibitor
Alternative Names:	XAV939 Wnt Signaling Inhibitor
Chemical Name:	3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	312.31

View Full Technical Details for XAV 939

Technical Data
Citations / Reviews (1)

Biological Activity for XAV 939

XAV 939 is a potent tankyrase (TNKS) inhibitor (IC₅₀ values are 4 and 11 nM for TNKS2 and TNKS1 respectively). Antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. XAV 939 inhibits proliferation of the β-catenin-dependent colon carcinoma cell line DLD-1. Promotes cardiomyocyte differentiation in mesoderm progenitor cells. Also used in neuronal differentiation protocols.

XAV 939 synthesized to cGMP guidelines also available.

For more information about how XAV 939 may be used, see our protocol: Accelerated Induction of Cortical Neurons from hiPSCs

Compound Libraries for XAV 939

XAV 939 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of XAV939 is reviewed on the chemical probes website.

Technical Data for XAV 939

M. Wt	312.31
Formula	C₁₄H₁₁F₃N₂OS
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	284028-89-3
PubChem ID	2726824
InChi Key	KLGQSVMIPOVQAX-UHFFFAOYSA-N
Smiles	OC1=C(CSCC2)C2=NC(C3=CC=C(C(F)(F)F)C=C3)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for XAV 939

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	6.25	20

Preparing Stock Solutions for XAV 939

The following data is based on the product molecular weight 312.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	16.01 mL	80.05 mL	160.10 mL
1 mM	3.20 mL	16.01 mL	32.02 mL
2 mM	1.60 mL	8.00 mL	16.01 mL
10 mM	0.32 mL	1.60 mL	3.20 mL

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Reconstitution Calculator

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References for XAV 939

References are publications that support the biological activity of the product.

Adler Inhibiting wnt signaling. Sci.Signal.
Wang Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/β-catenin signaling. ACS Chem. Biol. 2010 PMID: 21077691
Huang Tankyrase inhibition stabilizes axin and antagonizes wnt signalling. Nature 2009 PMID: 19759537