ZM 39923 hydrochloride

Name: ZM 39923 hydrochloride
Brand: Tocris Bioscience
SKU: 1367

Tocris Bioscience, part of Bio-Techne | Catalog # 1367

Citations (4)

COA / SDS

Potent, selective JAK3 inhibitor

Key Product Details

Description:	Potent, selective JAK3 inhibitor
Chemical Name:	3-benzylisopropylamino-1-naphthalen-2-yl-propan-1-one hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	367.92

View Full Technical Details for ZM 39923 hydrochloride

Technical Data
Citations

Biological Activity for ZM 39923 hydrochloride

ZM 39923 hydrochloride is a potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3). pIC₅₀ values are 7.1, 5.6, 4.4, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Breaks down in neutral buffer (t_½ = 36 mins, pH 7.43, 25°C) to form ZM 449829 (Cat. No. 1366).

Licensing Information

Sold with the permission of AstraZeneca Ltd.

Compound Libraries for ZM 39923 hydrochloride

ZM 39923 hydrochloride is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for ZM 39923 hydrochloride

M. Wt	367.92
Formula	C₂₃H₂₅NO.HCl
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	1021868-92-7
PubChem ID	176406
InChi Key	NJTUORMLOPXPBY-UHFFFAOYSA-N
Smiles	Cl.CC(C)N(CCC(=O)C1=CC=C2C=CC=CC2=C1)CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ZM 39923 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	36.79	100

Preparing Stock Solutions for ZM 39923 hydrochloride

The following data is based on the product molecular weight 367.92.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.72 mL	13.59 mL	27.18 mL
5 mM	0.54 mL	2.72 mL	5.44 mL
10 mM	0.27 mL	1.36 mL	2.72 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References for ZM 39923 hydrochloride

References are publications that support the biological activity of the product.

Brown Naphthyl ketones: a new class of janus kinase 3 inhibitors. Bioorg.Med.Chem.Lett. 2000 PMID: 10741557