11 beta-HSD Inhibitors: Small Molecules and Peptides
Type I 11-beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1, HSD11B1 or HSD1) is a microsomal glycoprotein enzyme, with an apparent mass of 36 kDa. HSD-1 catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. 11beta-HSD1 can also catalyze the reverse reaction, the conversion of cortisone to cortisol. 11beta-HSD1 has been detected in a wide range of rat and human tissues, including lung and testis, but highest amounts are expressed in the liver.
Human 11beta-HSD1 shares 79 and 77% sequence identity with mouse and rat 11beta-HSD1, respectively. There are at least 2 isoforms of 11beta-HSD. The other isoform, type II, is expressed predominantly in the kidney and placenta and catalyzes only the 11-beta-dehydrogenation reaction. High levels of cortisol can lead to visceral obesity and particular defects in the expression or function of 11beta-HSD1 have also been associated with insulin resistance and cognitive function.
2 results for "11 beta-HSD Inhibitors Small Molecules and Peptides" in Products
2 results for "11 beta-HSD Inhibitors Small Molecules and Peptides" in Products
11 beta-HSD Inhibitors: Small Molecules and Peptides
Type I 11-beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1, HSD11B1 or HSD1) is a microsomal glycoprotein enzyme, with an apparent mass of 36 kDa. HSD-1 catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. 11beta-HSD1 can also catalyze the reverse reaction, the conversion of cortisone to cortisol. 11beta-HSD1 has been detected in a wide range of rat and human tissues, including lung and testis, but highest amounts are expressed in the liver.
Human 11beta-HSD1 shares 79 and 77% sequence identity with mouse and rat 11beta-HSD1, respectively. There are at least 2 isoforms of 11beta-HSD. The other isoform, type II, is expressed predominantly in the kidney and placenta and catalyzes only the 11-beta-dehydrogenation reaction. High levels of cortisol can lead to visceral obesity and particular defects in the expression or function of 11beta-HSD1 have also been associated with insulin resistance and cognitive function.
Potent and selective 11β-hydroxysteroid dehydrogenase inhibitor
| Chemical Name: | N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide |
| Purity: | ≥98% (HPLC) |
Gap junction blocker. Also inhibitor of 11 β-hydroxysteroid dehydrogenase
| Chemical Name: | (3β,20β)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oic acid disodium |
| Purity: | ≥98% (HPLC) |
