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5-HT1B: Proteins and Enzymes
5-HT1B is a 7TM receptor for serotonin and is expressed on striatal neurons and Purkinje cells in the cerebellum. 5-HT1B ligation inhibits glycinergic signaling, appetite, circadian rhythym light responsiveness, and trigeminal-mediated nociception. It is an important pharmacologic target in the treatment of migrane headaches.
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