Caspase-4: Small Molecules and Peptides
Caspase-11 (also known as Caspase-4) is a cysteine-aspartic acid protease that functions in apoptosis initiation and the activation of proinflammatory cytokines. Pro-Caspase-11 is expressed as a zymogen which is cleaved into two subunits, p20 and p10. It is activated by an autocatalytic mechanism or by Caspase-8 mediated cleavage in response to ER stress or bacterial infection. Its expression and activation can be induced by exposure to LPS. Caspase-11 is one of several caspases associated with the inflammasome and plays an important role in the activation of proinflammatory cytokines. The active enzyme can cleave and activate Caspase-1 which in turn activates IL-1 beta.
Products:
3 results for "Caspase-4 Small Molecules and Peptides" in Products
3 results for "Caspase-4 Small Molecules and Peptides" in Products
Caspase-4: Small Molecules and Peptides
Caspase-11 (also known as Caspase-4) is a cysteine-aspartic acid protease that functions in apoptosis initiation and the activation of proinflammatory cytokines. Pro-Caspase-11 is expressed as a zymogen which is cleaved into two subunits, p20 and p10. It is activated by an autocatalytic mechanism or by Caspase-8 mediated cleavage in response to ER stress or bacterial infection. Its expression and activation can be induced by exposure to LPS. Caspase-11 is one of several caspases associated with the inflammasome and plays an important role in the activation of proinflammatory cytokines. The active enzyme can cleave and activate Caspase-1 which in turn activates IL-1 beta.
Products:
Potent and selective inhibitor of caspases 1, 5 and 4
| Purity: | ≥95% (HPLC) |
High affinity and selective caspase-4 and caspase 1/ICE inhibitor; orally bioavailable
| Alternate Names: | Belnacasan |
| Chemical Name: | N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-L-prolinamide |
| Purity: | ≥98% (HPLC) |
