CD68/SR-D1: Proteins and Enzymes

CD68 (macrosialin in mouse) is a 110 kDa type I transmembrane glycoprotein that belongs to the LAMP family of molecules. It contains a 300 amino acid (aa) extracellular region that is rich in threonine and serine, a likely attachment site for multiple carbohydrates. Human CD68 shares 74% aa sequence identity to mouse CD68 in the extracellular region. CD68 is found on monocytes and macrophages and serves as a scavenger receptor for oxidized LDL.