CRHBP: Proteins and Enzymes

CRHBP (Corticotrophin-releasing Hormone-Binding Protein) is a 37 kDa secreted glycoprotein that binds both CRH and urocortin in a 42 kDa extracellular complex. The molecule is approximately 300 amino acids in length and demonstrates five intrachain disulfide bonds. Species differences exist; human CRHBP is found in plasma while rodent and sheep CRHBP is limited to neuroendocrine tissues. CRHBP is presumed to either sequester CRH, rendering it unavailable to cells or transport it to target tissues.