Dectin-1/CLEC7A: Proteins and Enzymes
Dectin-1, also known as CLEC7A, is a transmembrane C-type lectin that participates in the innate immune response to fungal pathogens. It is expressed on the surface of monocytes, macrophages, myeloid DC, neutrophils, eosinophils, B cells, and CD4+ T cells. Dectin-1 selectively binds beta-glucan polymers, a major component of yeast and mycobacterial cell walls.
Dectin-1 mediates the phagocytosis of zymosan particles and intact yeast. Dectin-1 colocalizes with TLR2 in the presence of zymosan, and the two receptors cooperate in ligand recognition and the propagation of proinflammatory signaling. Dectin-1 also interacts with tetraspanin CD37 which increases its stability on the cell membrane and inhibits ligand-induced signaling.
Products:
4 results for "Dectin-1/CLEC7A Proteins and Enzymes" in Products
4 results for "Dectin-1/CLEC7A Proteins and Enzymes" in Products
Dectin-1/CLEC7A: Proteins and Enzymes
Dectin-1, also known as CLEC7A, is a transmembrane C-type lectin that participates in the innate immune response to fungal pathogens. It is expressed on the surface of monocytes, macrophages, myeloid DC, neutrophils, eosinophils, B cells, and CD4+ T cells. Dectin-1 selectively binds beta-glucan polymers, a major component of yeast and mycobacterial cell walls.
Dectin-1 mediates the phagocytosis of zymosan particles and intact yeast. Dectin-1 colocalizes with TLR2 in the presence of zymosan, and the two receptors cooperate in ligand recognition and the propagation of proinflammatory signaling. Dectin-1 also interacts with tetraspanin CD37 which increases its stability on the cell membrane and inhibits ligand-induced signaling.
Products:
| Source: | NS0 |
| Accession #: | NP_072092 |
| Applications: | Bind |
| Source: | NS0 |
| Accession #: | Q6QLQ4 |
| Applications: | Bind |
HEK293 Expressed
| Source: | HEK293 |
| Accession #: | Q9BXN2.1 |
| Applications: | BA |
| Applications: | AC |