Dendritic Cell Differentiation Kits: Cell Culture Products

Dendritic cells are a heterogeneous population of functionally homologous immune cells that act as key mediators of innate and adaptive immune responses. Under homeostatic conditions, dendritic cells are present in large numbers in areas of intense antigen exposure such as the skin, lung, and intestine, and can be difficult to isolate and harvest.

However, in response to an immune stimulus, CD14+ monocytes, which are present in high numbers in the periphery and circulation, can differentiate into inflammatory/monocyte-derived dendritic cells. Harvesting CD14+ monocytes from peripheral blood mononuclear cells and driving their differentiation into either immature or mature dendritic cells provides an abundant source of monocyte-derived dendritic cells for downstream studies.