DIDO1: Proteins and Enzymes

DIDO1 (Death-inducer obliterator 1; also DIO-1, C20orf158 and DATF-1) is a 245 kDa intracellular protein that belongs the DIO family of proteins. It is ubiquitous in expression and apparently serves multiple functions, depending on its splice variant. The standard form is a nuclear protein that maintains the integrity of mitotic checkpoint protein BubR1. An absence of DIDO1 results in centrosome amplification and unequal chromatin segregation. The best known short form (an 83 kDa isoform in mouse), by contrast, induces apoptosis by promoting transcription of caspase 9. It contains two NLSs, one PHD-type Zn finger region, a TFIIS domain, an SPOC protein-interaction domain, two Pro-rich segments and a C-terminal Arg-rich region. There are least 23 utilized phosphoryation sites.