Dkk-4: Lysates
Dickkopf related protein 4 (Dkk-4) is a member of the Dkk protein family of secreted Wnt antagonists. Dkk-1 and Dkk-4 antagonize Wnt/beta-catenin signaling by direct high affinity binding to the Wnt coreceptor LRP5/6 and inhibiting interaction of LRP5/6 with the Wnt-Frizzled complex. Dkk-1 and Dkk-4 also bind the transmembrane proteins Kremen-1 and Kremen-2 with high affinity. Kremen-2 can form a ternary complex with Dkk-1 or Dkk-4 plus LRP5/6 to trigger internalization of the complex and removal of LRP6 from the cell surface. Thus, Dkk-1/4 and Kremens function synergistically to antagonize LRP5/6-mediated Wnt activity.
Products:
1 result for "Dkk-4 Lysates" in Products
1 result for "Dkk-4 Lysates" in Products
Dkk-4: Lysates
Dickkopf related protein 4 (Dkk-4) is a member of the Dkk protein family of secreted Wnt antagonists. Dkk-1 and Dkk-4 antagonize Wnt/beta-catenin signaling by direct high affinity binding to the Wnt coreceptor LRP5/6 and inhibiting interaction of LRP5/6 with the Wnt-Frizzled complex. Dkk-1 and Dkk-4 also bind the transmembrane proteins Kremen-1 and Kremen-2 with high affinity. Kremen-2 can form a ternary complex with Dkk-1 or Dkk-4 plus LRP5/6 to trigger internalization of the complex and removal of LRP6 from the cell surface. Thus, Dkk-1/4 and Kremens function synergistically to antagonize LRP5/6-mediated Wnt activity.
Products:
| Applications: | WB |
![Western Blot: Dkk-4 Overexpression Lysate [NBL1-09905]](https://resources.bio-techne.com/images/products/DKK4-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-09905-img0002.jpg "Western Blot: Dkk-4 Overexpression Lysate [NBL1-09905]")