Fas Ligand/TNFSF6: Lysates
Fas Ligand (FasL), also known as CD178, CD95L, or TNFSF6, is a transmembrane protein homotrimer that binds to Fas/CD95 and triggers apoptosis in the Fas-expressing cell. Fas Ligand also binds the soluble decoy receptor DcR3. It is expressed on activated Th1 cells, CD8+ cytotoxic T cells, and NK cells.
A soluble form can be released which remains trimeric and retains the ability to bind Fas. Fas Ligand-induced apoptosis plays a central role in the development of immune tolerance and the maintenance of immune-privileged sites. Tumor cells can evade immune surveillance by upregulating Fas Ligand to kill tumor-infiltrating lymphocytes. In gld mice, a Fas Ligand point mutation is the cause of severe lymphoproliferation and systemic autoimmunity.
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Fas Ligand/TNFSF6: Lysates
Fas Ligand (FasL), also known as CD178, CD95L, or TNFSF6, is a transmembrane protein homotrimer that binds to Fas/CD95 and triggers apoptosis in the Fas-expressing cell. Fas Ligand also binds the soluble decoy receptor DcR3. It is expressed on activated Th1 cells, CD8+ cytotoxic T cells, and NK cells.
A soluble form can be released which remains trimeric and retains the ability to bind Fas. Fas Ligand-induced apoptosis plays a central role in the development of immune tolerance and the maintenance of immune-privileged sites. Tumor cells can evade immune surveillance by upregulating Fas Ligand to kill tumor-infiltrating lymphocytes. In gld mice, a Fas Ligand point mutation is the cause of severe lymphoproliferation and systemic autoimmunity.
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| Applications: | WB |
![Western Blot: Fas Ligand/TNFSF6 Overexpression Lysate [NBL1-10600]](https://resources.bio-techne.com/images/products/Fas-Ligand-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-10600-img0002.jpg "Western Blot: Fas Ligand/TNFSF6 Overexpression Lysate [NBL1-10600]")