HO-2/HMOX2: Proteins and Enzymes

HO-1 and 2 are microsomal enzymes required for the metabolism of heme to biliverdin in a reaction that also produces carbon monoxide. Splenic HO-1 expression is induced by heme and other non-heme compounds, whereas HO-2 is expressed constitutively. These enzymes are implicated in a variety of disease states due to their roles as anti-oxidants.