Legumain/Asparaginyl Endopeptidase: Proteins and Enzymes

Legumain is a lysosomal cysteine protease that plays a pivotal role in the endosomal/lysosomal degradation system. Legumain deficiency causes the accumulation of pro-Cathepsins B, H and L, another group of lysosomal cysteine proteases. Overexpression of Legumain in tumors is significant for invasion/metastasis. Also known as Asparaginyl Endopeptidase, it specifically cleaves peptide bonds with Asn or Asp at the P1 position.