LIN-41: Proteins and Enzymes

LIN-41 (lineage-41; also TRIM/tripartite motif-containing protein 71) is a 94 kDa (predicted) cytosolic member of the RBCC (RING finger, B-Box Coiled-Coil) family of proteins. It is expressed in developing limbs, DRG and branchial arches and apparently regulates the timed expression of proliferation and differentiation-associated genes. Human LIN-41 is 868 amino acids (aa) in length. It contains a RING-type zinc finger region (aa 12 - 95), a His-rich segment (aa 146 - 157), two B Box zinc fingers that bind DNA (aa 194 - 314), a coiled-coil motif that binds protein (aa 391 - 427), one filamin repeat and six NHL repeats that regulate gene translation (aa 593 - 868). Over aa 386 - 868, human LIN-41 is 97%, 95%, and 94% aa identical to canine, mouse, and chicken LIN-41, respectively.