MCHR1: cDNA Clones

MCHR1 is the receptor for melanin-concentrating hormone MCH. It is coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis. The hypothalamic neuropeptide MCH, and its only receptor MCHR1, play important roles in energy homeostasis, anxiety, and sleep regulation. MCHR1 is also important in regulating metabolic responses upon various environmental stimuli such as high-fat diet.