MKK6: Proteins and Enzymes

MKK6 and the closely related MKK3 are activated by pro-inflammatory cytokines and environmental stresses. Both MKK3 and MKK6 are dual specificity protein kinases, phosphorylating and activating the p38 MAP kinases at Thr and Tyr positions within the phosphoacceptor sequence Thr-Gly-Tyr. Activation of MKK6 occurs through phosphorylation at Ser207 and Thr211 by several upstream MAPK kinase kinases, including ASK1 and TAK1.