MN1: Proteins and Enzymes
The MN1 gene, which resides on chromosome 22, encodes a 1,319 amino acid protein. The ETV6/TEL gene has been reported to fuse to MN1. The MN1-TEL fusion protein, encoded by the translocation (12;22)(p13;q11) in myeloid leukemia, is a transcription factor with transforming activity. Defects in MN1 (meningioma 1) may be a cause of meningiomas, slowly growing benign tumors derived from the arachnoidal cap cells of the leptomeninges, the soft coverings of the brain and spinal cord.
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MN1: Proteins and Enzymes
The MN1 gene, which resides on chromosome 22, encodes a 1,319 amino acid protein. The ETV6/TEL gene has been reported to fuse to MN1. The MN1-TEL fusion protein, encoded by the translocation (12;22)(p13;q11) in myeloid leukemia, is a transcription factor with transforming activity. Defects in MN1 (meningioma 1) may be a cause of meningiomas, slowly growing benign tumors derived from the arachnoidal cap cells of the leptomeninges, the soft coverings of the brain and spinal cord.
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Applications: | WB, ELISA, MA, AP, PAGE |