NHE3/SLC9A3: Proteins and Enzymes

Na(+)/H(+) exchanger 3 (NHE3), also known as SLC9A3, plays an important role in neutral Na(+) transport in mammalian epithelial cells. SLC9A3 is acutely up- and down-regulated in response to some G protein-coupled receptors, tyrosine kinase receptors, and protein kinases. It is involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. SLC9A3 was demonstrated to be a modifier of intestinal disease in a murine model of CF.