NIK/MAP3K14: Proteins and Enzymes

NIK (nuclear factor inducing kinase), also called MAP3K14 or MAP4K4, is a widely expressed 947 amino acid (aa), approximately 100 kDa cytoplasmic protein of the MAP kinase family. NIK participates in a non-canonical NFkappaB signaling cascade in which its activity and expression are elevated by TNF and related ligands. NIK activates IKK alpha/beta, which releases NFkappaB subunits for translocation to the nucleus.