PIGC: Proteins and Enzymes

PIGC, also known as Phosphatidylinositol N-acetylglucosaminyltransferase subunit C, is 297 amino acids in length and approximately 34 kDa. PIGC is an important player in GPI anchor biosynthesis because it catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol. Current research on PIGC is being performed relating to several diseases and disorders including malaria and lassa fever. PIGC has also been shown to have interactions with PIGA, DPM2, KLF10, PIGQ and ZHX1 in pathways such as GPI anchor biosynthesis and metabolic pathways.