Polycystic kidney disease protein 1-like 2: Proteins and Enzymes

Polycystic kidney disease protein 1-like 2 encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores. Two transcript variants encoding different isoforms have been found for this gene. FUNCTION: May function as an ion-channel regulator. May function as a G-protein-coupled receptor. SUBUNIT: May interact via its C-terminus with GNAS and GNAI1. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.