SDNSF/MCFD2: Proteins and Enzymes

SDNSF (stem cell-derived neural stem/progenitor cell supporting factor ), also known as MCFD2 (multiple coagulation factor deficiency 2), was described as a secreted molecule from adult hippocampal neural stem/progenitor cells (ANSC). SDNSF functions as an autocrine/paracrine factor to maintain neurogenesis in the central nervous system. It is a component of the MCDF2-LMAN1 complex that functions as a specific cargo receptor for the ER to Golgi transport of proteins. Mutations in MCFD2 causes factor 5 and factor 8 combined deficiency.